secobarbital will lower the level or effect of etoposide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.secobarbital will decrease the level or effect of budesonide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.secobarbital will lower the level or effect of levonorgestrel oral/ethinylestr